For example, miR-375-3p suppresses the proliferation and metastasis of bladder cancer via target frizzled-8 [18]; miR-96 decreases proliferation, migration, and invasion and can trigger apoptosis in pancreatic cancers [19]; miR-362-3p induces cell cycle arrest through targeting of E2F1, USF2, and PTPN1, which are involved in the recurrence of CRC [20]; and miR-425-5p has been shown to participate in the pathogenesis of KRAS-mutated CRC and thereby increase tumor aggressiveness [21]. This evidence concerns the gene E2F1 and colorectal carcinoma.