Combined with the regulatory role of IL-18 in the immune system and a protective role in the gastrointestinal tract, the expression of IL-18 was found to be prognostic in CRC, where a high level of IL-18 is favored (https://www.proteinatlas.org/search/Expression+of+IL18+in+Colorectal+Cancer) [7]. The gene discussed is IL18; the disease is colorectal carcinoma.