I constructed an 8‐lncRNA signature (LINC00567, LINC00996, MTOR‐AS1, PRKG1‐AS1, RAB11B‐AS1, RPS6KA2‐AS1, SH3BP5‐AS1, ZNF451‐AS1) that may have potential as an independent prognostic factor of HNSCC. Here, PRKG1 is linked to head and neck squamous cell carcinoma.