This subset of cancers is highly sensitive to upstream inhibitors of Wnt signaling pathway such as anti‐FZD and anti‐R‐spondin antibodies as well as PORCN inhibitors such as ETC‐159 (Gurney et al, 2012; Jiang et al, 2013; Madan et al, 2016). The gene discussed is PORCN; the disease is cancer.