To test whether PORCN inhibition causes a decrease in HR and FA genes in additional Wnt‐addicted cancer models, we examined RNA‐seq data from a colorectal cancer patient‐derived xenograft (CRC PDX) with a RSPO3 translocation that was treated with ETC‐159 (Madan et al, 2016). Here, PORCN is linked to colorectal carcinoma.