Wnt signaling through a β‐catenin/MYBL2 pathway regulates the expression of BRCA1, BRCA2, RAD51, and FANCD2. This study uncovers a role for Wnt/β‐catenin signaling in the regulation of homologous recombination DNA repair pathway in intestinal stem cells and in cancer and demonstrates that inhibition of Wnt signaling confers a BRCA‐like phenotype, providing a novel therapeutic opportunity for Wnt high cancers. The gene discussed is MYBL2; the disease is cancer.