Consistent with this being a general phenomenon in Wnt‐addicted cancers, HR pathway gene expression as analyzed by qRT–PCR was also decreased upon ETC‐159 treatment of an RNF43 mutant (G371fs) pancreatic cancer patient‐derived xenograft as well as in AsPC‐1 pancreatic cancer and EGI‐1 cholangiocarcinoma cells (Figs 2H and I, and EV1G). Here, RNF43 is linked to pancreatic neoplasm.