Since Wnt‐addicted cells are substantially more sensitive to PORCN inhibitors when grown in suspension, the screen was performed in the Wnt‐addicted RNF43‐mutant pancreatic cancer cell line HPAF‐II using soft agar colony formation as the readout (Madan et al, 2016; Zhong et al, 2019). Here, RNF43 is linked to pancreatic neoplasm.