We observed that, similar to the regulation of DNA repair genes, MYBL2 expression was regulated by Wnt signaling in AsPC‐1 orthotopic xenografts, as well as in a pancreatic cancer PDX with an RNF43 mutation, and a colorectal cancer PDX with an R‐spondin translocation (Fig 5H–J). The gene discussed is RNF43; the disease is familial pancreatic carcinoma.