Human SATB2 is a highly evolutionarily conserved chromatin remodelling gene located on chromosome 2q33.1,9 and mutation of SATB2 induces not only severe bone‐associated conditions, including cleft palate, facial cleft, micrognathia and alveolar bone dysplasia10, 11, 12, 13 but also odontogenic abnormalities, including missing teeth, delayed tooth and root development.14, 15, 16. The gene discussed is SATB2; the disease is cleft palate.