Generally, high-fat diet (HFD)-induced insulin resistance (IR) is caused by the reduction of GLUT4 translocation through a defective insulin signaling pathway [39], and in type 1 diabetes mellitus (T1DM) patients, the translocation and activation of GLUT4 does not occur due a lack of insulin production. This evidence concerns the gene SLC2A4 and type 1 diabetes mellitus.