Interestingly, Zhu et al. reported on longer PFS and OS in breast cancer patients with low expression of SPHK1 and a significant association of high SPHK1 expression with poor prognostic parameters (presence of lymph node metastasis, number of positive lymph nodes and presence of distant metastasis). Here, SPHK1 is linked to metastatic malignant neoplasm in the lymph nodes.