Neutrophils can also be activated by the cancer cell-derived secretions, with a recent study by Teijeira et al. reporting that cancer cell-derived chemokines (IL-8, CXCL1, CXCL2, CXCL8) activate the CXCR1 and CXCR2 receptors on neutrophils, resulting in the formation of neutrophil extracellular traps (NETs)59. The gene discussed is CXCL1; the disease is cancer.