For instance, L. Yang et al. demonstrated distinct stimulatory activity of CpG-ОDN D-SL03 derivative,which was able to: (i) activate human B cells, NK cells andT cells in vitro; (ii) intensity the expression of CD80, CD86and HLA-DR in mononuclear cell cultures, and (iii) furnishanti-cancer effects in a murine model of breast cancer in vivo(Yang et al., 2013). Here, CD80 is linked to breast cancer.