Immunohistochemical analysis and morphometric evaluationof the expression of apoptosis molecular-cell regulatorsof BCL-2 family proteins – the antiapoptotic protein Bcl-2and the proapoptotic protein Bad – in the liver cells of maledb/ db mice were carried out at different stages of obesity andtype 2 diabetes mellitus development. This evidence concerns the gene BAD and obesity due to melanocortin 4 receptor deficiency.