Insulin sensitivity at the whole bodylevel (blood glucose level, insulin resistance index), as well as hepatic expression of insulin signal transduction genes(Irs2 and Pik3cd ) in SHAM females was higher than that inSHAM males, which coincides with data obtained on intactanimals (Parks et al., 2015; Torre et al., 2017; Yakovleva etal., 2017). The gene discussed is IRS2; the disease is Insulin resistance.