FGF21 influenceon FI in female rodent was not studied, but in males, FGF21was shown previously to increase FI in rats (Recinella et al.,2017), mice with diet-induced obesity (Coskun et al., 2008),and to increase protein intake while reducing carbohydrateintake in normal mice, and the later effect was mediated viaCNS (Larson et al., 2019). Here, FGF21 is linked to obesity due to melanocortin 4 receptor deficiency.