For example, iPSC-ECs were generated to study the BMPR2 (bone morphogenetic protein receptor type II) mutation that causes pulmonary arterial hypertension (PAH) and PAH-specific iPSC-ECs exhibited decreased tube formation, LDL uptake (104), adhesion, migration, and survival (105). The gene discussed is BMPR2; the disease is pulmonary arterial hypertension.