UCP2 and Sepsis: Plenty of evidences have suggested the involvement of lipid synthesis in sepsis (Green et al., 2016), and one of the elucidated mechanisms was that lipid synthesis in macrophages can be inhibited by the deprivation of mitochondrial uncoupling protein-2 (UCP2), which was later distinguished as a potential therapeutic target for sepsis through in vivo and in vitro studies (Moon et al., 2015).