Gq-coupled receptors are thought to play a central role in the induction of pathological LVH in response to agonists, such as angiotensin II (AngII), catecholamines and endothelin-1, or increased mechanical stress associated with hypertension, aortic stenosis and pathological ventricular remodeling after myocardial injury (D’Angelo et al., 1997; Adams et al., 1998; Akhter et al., 1998; Paradis et al., 2000; Frey and Olson, 2003). This evidence concerns the gene AGT and Hypertension.