ACE and hypertensive heart disease: Our results may help explain why angiotensin converting enzyme inhibitors and angiotensin receptor blockers, although effective and frequently prescribed anti-hypertensive therapies, have not been shown to be more effective in reducing the morbidity and mortality of hypertensive heart disease than less specific anti-hypertensive agents, including diuretics (Psaty et al., 2003; Xue et al., 2015).