To explain CFRD, several studies have shown that CFTR played a vital role in the regulation of insulin secretion and β cell function (Tofe et al., 2005; Noronha et al., 2011; Konrad et al., 2013; Edlund et al., 2014; Guo et al., 2014). Here, CFTR is linked to cystic fibrosis-related diabetes.