One of the prevailing mechanistic beliefs is that CFRD results from defective insulin secretion of pancreatic β-cell, which is due to the combination of chronic pancreatitis and eventual loss of the islet cells (Cucinotta et al., 1994; Marshall et al., 2005; Costa et al., 2007; Mohan et al., 2009; Guo et al., 2014). This evidence concerns the gene INS and cystic fibrosis-related diabetes.