IGFBP7 and Insulin resistance: The role of IGFBP7 and IL6 in the induction of insulin resistance and cachexia is further supported by their increased plasma titer in patients suffering from diseases often accompanied by cachexia, such as morbid obesity, cancer, chronic obstructive pulmonary disease, acute kidney diseases, and liver fibrosis (Liu et al., 2015; Gunnerson et al., 2016; Ruan et al., 2017; Martínez-Castillo et al., 2020).