In the present study, we aimed to determine whether EGR1 binds to the promoter region of miR-203a and regulates its expression; to confirm whether WT1, BMI1, and XIAP are target genes regulated by miR-203a; and to further clarify that the EGR1-miR-203a-target genes (WT1/BMI1/XIAP) regulatory network participates in the occurrence and development of CML. The gene discussed is BMI1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.