TNFRSF1A and chronic obstructive pulmonary disease: Tan et al. (2017) evaluated the levels of serum-derived exosomes in COPD patients during exacerbations and in stable disease. These patients presented higher levels of serum-derived exosomes, which correlated with the levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble tumor necrosis factor receptor 1 (sTNFR1) expression, suggesting a role of these vesicles during COPD exacerbations (Tan et al., 2017).