FGF7 and acute respiratory distress syndrome: In animal models of LPS-induced ARDS, intratracheal instillation of human MSC-derived MVs reduced lung edema (Zhu et al., 2014; Wang et al., 2020); however, knockdown of angiopoietin-1 or keratinocyte growth factor (KGF) mRNA in MSC-derived MVs abrogated these protective effects (Tang et al., 2017).