This aggressive pediatric B-cell non-Hodgkin lymphoma is caused by the EBV, which induces genomic instability in the B-cell that results in hyperproliferation (393, 394) and it is associated with unique TP53 mutations that are clustered between codons 213 to 248 (395–397). The gene discussed is TP53; the disease is B-cell non-Hodgkin lymphoma.