To establish the association of vitamin D variants and related genes with breast cancer, El-Shorbagy et al. (133), Abd-Elsala et al. (134) and Shaker & Senousy (135) showed that polymorphisms in the vitamin D receptor (VDR) increases the risk of breast cancer in Egyptian women who carry the ATT haplotype. The gene discussed is VDR; the disease is breast carcinoma.