CCN2 and breast carcinoma: Studies suggested that breast cancer cells secrete osteolytic factors such as interleukin (IL)‐1, IL‐6 and IL‐8, connective tissue growth factor (CTGF) and matrix metallopeptidase (MMP)‐1 leading to exacerbation of osteolysis (Kim et al., 2020; Sabokbar et al., 2016).