Liu et al. [32] demonstrated that p53-miR-15a/16-Mcl-1 axis may be a critical pathway in the regulation of apoptosis and drug resistance in CLL, considering the impact of quercetin in decrease the viability of radioresitant B-1 cells by modulate the levels of miR15a/16-Bcl-2 could point an important adjuvant in the CLL treatment. This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.