We have previously reported the role of the transcriptional factor NF-E2-related factor 2 (Nrf2) in cancer-TAM interactions in hepatocellular carcinoma (HCC) and pancreatic cancer [15] and cancer-CAF interactions through IL-6 and CXCL10 in pancreatic cancer [16]. This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.