In fact, a matching-adjusted indirect comparison (MAIC) [40] between these drugs in crizotinib-refractory ALK+ NSCLC patients (using clinical data from the ALTA trial – date February 21, 2017 –, ASCEND-1 [41], ASCEND-2 [42], NP28761 [43] and NP28673 [44]) suggested that brigatinib may have prolonged PFS and OS versus ceritinib and prolonged PFS versus alectinib in patients after progression with crizotinib. Here, ALK is linked to non-small cell lung carcinoma.