SIRT1 and neoplasm: In order to assess the possible role of each drug on brain metastasis, eight protein/gene effectors known to have a more important role in brain metastasis than in primary tumours were considered: FGFR1 [61–63]; Ki-67 [64, 65], ROBO1 [66]; S100A7 [67, 68]; S100B [69, 70]; SIRT1 [71]; SLIT2 [72]; and VEGFA [61, 67].