ALK and non-small cell lung carcinoma: In the phase III trial ALTA-1L (https://clinicaltrials.gov/: NCT02737501) brigatinib was associated with a higher intracranial objective response rate (iORR) (78%) in individuals with ALK TKI-naive ALK+ NSCLC with baseline brain metastases compared to crizotinib (26%) [47].