ALK and non-small cell lung carcinoma: Second generation ALKi ceritinib, alectinib and brigatinib have been approved for the treatment of ALK+ NSCLC patients after treatment with crizotinib (ceritinib in 2014 [20] and in 2015 [21]; alectinib in 2015 [22] and in 2017 [23], while brigatinib in 2017 [24] and 2018 [25] for the United States and Europe, respectively) and as first-line TKI treatments (in 2017, ceritinib [26, 27] and alectinib [23, 28] and, in 2020, brigatinib [25, 29], for the United States and Europe, respectively).