KLF4 and acute myeloid leukemia: To further evaluate whether DNA methylation is involved in the regulation of KLF4 expression, we treated a panel of AML (NB4, THP-1, MonoMac-6, SKM-1), CML (K562), and EBV-transformed lymphoblastoid (LCL) cell lines with the hypomethylating agent 5-Azacytidine (5-aza).