The MT-ND4L gene has been associated with obesity (Flaquer et al., 2014) and is a mitochondrial encoding subunit of respiratory complex I. In the present study, the missense mutation MT:10609T > C in the MT-ND4L gene was negatively correlated with risk of obesity. This evidence concerns the gene MT-ND4L and obesity due to melanocortin 4 receptor deficiency.