Recent successes using high throughput screening of small molecule libraries identified several inhibitors of EHMT2/G9a, a histone 3 lysine 9 methyltransferase, that were capable of reactivating the expression of paternally expressed SNRPN and SNORD116 from the maternal chromosome, both in cultured PWS cell lines and in a PWS mouse model (Kim et al., 2017, 2019). This evidence concerns the gene SNORD116 and Prader-Willi syndrome.