IFI16 and metastatic malignant neoplasm in the lymph nodes: Next, we evaluated the relationship between expression levels of IFI16 and clinical-pathological parameters (lymph node metastasis, stage, and grade) in ccRCC patients (Figures 1B–D): IFI16 was highly expressed in ccRCC patients with lymph node metastasis, higher tumor stages, and higher histopathological grades.