IFI16 and nonpapillary renal cell carcinoma: ROC curves for IFI16 expression, histopathological grade, and the combination of the two were used to evaluate the predictive efficiency of ccRCC patients with IFI16. IFI16 expression alone could be used to evaluate the predictive efficiency of patients; the AUC was 0.608 (95% CI: 0.534–0.682, P = 0.002), and the sensitivity and specificity were 55.4 and 66.9%, respectively.