Given that BCR stimulation induces activation of PLC, which cleaves GPI anchors, we assessed the ability of PLC to cleave CD52 by treating PBMCs from HC (n = 5) and SLE (n = 5) donors with the enzyme, and analyzed CD52 surface expression on treated and untreated cell populations (35). Here, HSPG2 is linked to systemic lupus erythematosus.