CD52 and mantle cell lymphoma: To delineate the role of surface bound CD52, we used CRISPR-Cas9 to generate CD52 knockout JeKo-1 cells, a mantle cell lymphoma cell line with high and homogenous expression of CD52 which is in contrast to expression levels in other commonly used B cell lines [(32), p. 52; (33), p. 52] (Figure 3A).