Given that BCR stimulation induces activation of PLC, which cleaves GPI anchors, we assessed the ability of PLC to cleave CD52 by treating PBMCs from HC (n = 5) and SLE (n = 5) donors with the enzyme, and analyzed CD52 surface expression on treated and untreated cell populations (35). This evidence concerns the gene CD52 and systemic lupus erythematosus.