ETV5 and cancer: Additionally, we observed a paradoxical positive correlation between ETV5 promoter hypermethylation (Figure 1F) and higher expression in cancer tissue (Figure 1B) suggesting that hypermethylation may facilitate gene expression either by the opening of chromatin (Smith et al., 2020) or mechanical inhibition of transcriptional repressor binding (Nabilsi et al., 2009) or allowing transcription from an alternative promoter (Renaud et al., 2007).