ETV5 overexpression stimulates CRC angiogenesis through activation of VGFR by PDGFR-β/Src/STAT3 signaling (Llaurado et al., 2012) and increases bevacizumab resistance through AKT, ERK, and p38 signaling decreasing overall survival of the patients (Llaurado et al., 2012). The gene discussed is AKT1; the disease is colorectal carcinoma.