In our previous studies, we noticed that survivin overexpressed in viral myocarditis and the up-regulation of survivin negatively correlated with the expression of Cleaved Caspase-3, suggesting that survivin may protect cardiomyocytes from CVB3- induced apoptosis (Li et al., 2019; Wu et al., 2020; Yu et al., 2015). The gene discussed is BIRC5; the disease is viral myocarditis.