AKT1 and cocaine dependence: This network illustrated that GH may indirectly influence or directly interact with major targets which are involved in pathways related to HPA axis (such as pathways in cancer, proteoglycans in cancer), dopamine (such as neuroactive ligand-receptor interaction, cocaine addiction, dopaminergic synapse) and neural plasticity (such as cAMP signaling pathway, glutamatergic synapse, gap junction, PI3K-Akt signaling pathway and estrogen signaling pathway) to achieve the antidepressant effects.