Among those signaling mediators, TNF-α, IL-1, IL-6, IL-8, and IL-1β, NF-κB, MMPs, MAPK, and COX-2 seem to play critical roles in the pathogenesis of COVID-19 and associated lung injury (Fakhri et al., 2020b; Liu Y. et al., 2020; Merad and Martin, 2020). The gene discussed is IL1B; the disease is COVID-19.