SLC22A1 and type 2 diabetes mellitus: However, the molecular mechanism of interaction between the drug and transporter is still unclear; therefore, this study proposes a potential structural model for the diffusion and interaction of this drug with the hOCT1 transporter, as well as the identification of the effect G401S, S189L, and R206C at the topological and electron structure levels, as well as explore the presence of these rare functional variants in a sample of T2DM patients from Colombia.