The B-cell receptor (BCR) signaling pathway plays a vital role in the pathogenesis of several B-cell malignancies, including chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), and mantle-cell lymphoma (MCL) (Stevenson and Caligaris-Cappio, 2004; Gururajan et al., 2006; Merolle et al., 2018). Here, BCR is linked to B-cell chronic lymphocytic leukemia.