NOS3 and endothelial dysfunction: Aberrant NOX activation could promote eNOS dysregulation and uncoupling, leading to NO bioavailability reduction, superoxide generation, and ONOO− formation, which create a toxic cycle of oxidative stress and consequently aggravate endothelial dysfunction (Lee et al., 2017; Meza et al., 2019; Siragusa and Fleming, 2016).