APP and Alzheimer disease: Furthermore, Kummer et al. (2011) reported that nitrated Aβ was detected in the core of plaques of APP/PS1 double transgenic mice and brains of AD patients, and Guivernau et al. (2016) also observed nitrotyrosine immunoreactivity in the plaques of AD patients’ brain, indicating that Aβ can be nitrated in vivo.