The first set of genes were generated by combining the differentially expressed genes (DEGs) from our published single-cell RNA-seq (scRNA-seq) data of Ref-1 knockdown23 and correlating these DEGs with genes that were significantly upregulated in MPNST samples compared to NF1-derived neurofibroma Schwann cells (Fig. 5). The gene discussed is APEX1; the disease is malignant peripheral nerve sheath tumor.