MYCN and neuroblastoma: We found that the MYCN-amplified neuroblastoma cell lines (CHP134, IMR-32, Kelly, LAN-1 and SK-N-BE(2)-C) with high MYCN expression had the greatest sensitivity to the cytotoxic effects of the combination treatment in comparison with MYCN non-amplified cell lines (SH-SY5Y, SK-N-AS, and SK-N-FI) (Fig. 3a).