Yuan et al.24 demonstrated that ANXA2 was correlated with the proliferation and invasion of breast cancer cells, and the mechanism was phosphorylation of ANXA2 enhanced STAT3 activation, increasing the expression of cyclin D1 and MMP2/9, which were the key target genes of STAT3 playing vital roles in cell proliferation and invasion. The gene discussed is ANXA2; the disease is breast carcinoma.