Non-invasive predictive model using serum data is not new to liver fibrosis prediction, since the aspartate transaminase to platelet ratio index (APRI), the fibrosis index based on the four factors (FIB-4), the red cell distribution width-platelet ratio (RPR) and the gamma-glutamyl transpeptidase-to-platelet ratio (GPR) have been used for the detection of liver fibrosis and cirrhosis in medical practice for years13–16. This evidence concerns the gene GGTLC1 and Cirrhosis.