CYSLTR1 (+ 348, Fig. 3A), CCDC88C (+ 125,722, Fig. 3B), and ADORA2B (+ 1339, Fig. 3C) gene methylations were all positively correlated with post-BD FEV1%predicted, while TIGIT gene methylation (− 173, Fig. 3D) was negatively correlated with post-BD FEV1%predicted. This evidence concerns the gene TIGIT and Behcet disease.