The marker with the strongest association to poor prognosis in multivariate analysis with adjustments for age, sex, metastatic disease and medical treatments (oral anticoagulants, low molecular weight heparins [LMWHs] and corticosteroids) was NE, followed by sP-selectin, H3Cit-DNA and G-CSF. The gene discussed is CSF3; the disease is metastatic neoplasm.