Considered that epigenetic alterations, such as O6-methylguanine DNA methyltransferase (MGMT) methylation, facilitate carcinogenesis30, we investigated the correlation between B2M and MGMT methylation and found that B2M was significantly downregulated in methylated samples in pan-gliomas and LGGs (Fig. 1B). This evidence concerns the gene MGMT and central nervous system cancer.