In pan-gliomas and LGG samples, the sensitivity and specificity of B2M expression in predicting the IDH wild-type state were high with the area under the curve (AUC) value of 78.8% and 70.8%, respectively (Fig. 1E), which IDH wild-type state has been previously proved with worse outcome and tumor progression in gliomas31. This evidence concerns the gene B2M and central nervous system cancer.