The relationship between B2M and seven inflammatory activity related signatures was then explored in pan-gliomas (Fig. 5C) and LGG (Fig. 5D), B2M expression had positive correlation with HCK, LCK, MHC-I, MHC-II, STAT1 and interferon metagenes, and negative correlation with IgG metagene expression. Here, HCK is linked to central nervous system cancer.