We also observed variable levels and distributions of H3K27ac nearby MYC broad H3K4me3 domains, including dynamic cancer type-specific patterning of intergenic H3K27ac marked enhancers (Supplementary Fig. 21), where broad H3K4me3 levels were more highly correlated with H3K27ac levels at promoter regions relative to intergenic H3K27ac levels. Here, MYC is linked to cancer.