PIK3R1 and acute myeloid leukemia: We found that GLI1 overexpression resulted in increased phosphatidylinositol (3,4,5)-trisphosphate (PIP3) levels in THP-1/OE and U937/OE cells (Fig. 3C), and the expression levels of PIK3R1 and AKT3 were positively correlated with the GLI1 expression level in AML patients (Fig. 3D).