HSP90AA1 and cancer: Furthermore, a clinical PDAC tissue array (named as Renji cohort) showed that HSP90 expression was significantly upregulated in PDAC tissues compared to adjacent tissues (Supplementary Fig. 3d), and Kaplan–Meier analysis further revealed that high expression of HSP90 in cancer tissues was associated with a poor prognosis in both the Renji and TCGA cohorts (Supplementary Fig. 3e, f).