TP53 and neoplasm: To explore cellular diversity in murine PDAC, we generated single-cell RNA-seq profiles from the solid tumors of murine PDAC tumor samples derived from Kras+/LSL-G12D; Trp53+/LSL-R172H; Pdx1-Cre (KPC) mice, which well recapitulate the progression of human PDAC and are widely used for PDAC drug evaluation (Fig. 1a, b).