In fact, animal studies have shown that inhaled IFN could effectively repair the antiviral immunity impaired by GC and prevent viral infections.16 Another potential advantage of inhaled IFN is the low distribution of IFN to those air-impenetrable lung lesions where IFN may play a more damaging role in further exacerbating inflammation and disrupting tissue repair.21,22 Since GC is given systemically, they can still reach these regions via blood vessels to suppress inflammation. This evidence concerns the gene IFNA1 and viral infectious disease.