Among the 192 candidate SNPs, 8 SNPs within microRNA binding sites were related to breast cancer OS (P<0.05), with and without adjustments for age at diagnosis, education, occupation, age at menarche, number of live births, breastfeeding duration, abortion, menopause, TNM stage, tumor size, histopathologic classification, grade, lymph node, ER, PR, and HER2 (Table 3 and Supplementary Figure 1). The gene discussed is ESR1; the disease is breast carcinoma.