Among the 8 SNPs identified from stage I, the SNP rs10878441 in LRRK2 gene (the duplex structure between miR-550-3p and LRRK2 was shown in Supplementary Figure 3) was significantly associated with the OS of breast cancer (AA vs CC: HR=2.21, 95% CI: 1.11-4.42, P=0.024) (Table 4). This evidence concerns the gene LRRK2 and breast cancer.