RAD54L was significantly over-expressed in squamous cell lung carcinoma tissues (fold change=6.491; P=1.95E-05) from the Bhattacharjee lung dataset, squamous cell lung carcinoma (fold change=2.832; P=1.59E-13) and large cell lung carcinoma (fold change=3.442; P=3.52E-07) tissues from the Hou lung dataset, and lung adenocarcinoma tissues (fold change=4.994; P=7.42E-10) from the Okayama lung dataset. The gene discussed is RAD54L; the disease is lung large cell carcinoma.