Moreover, NLRP3, another critical NLR family member, has been proved to modulate the progression of lung cancer, such as: tumor-derived exosomal TRIM59 activated NLRP3 inflammasome signaling pathway to promote lung cancer progression by IL-1β secretion [26]; NLRP3 could also promote metabolic reprogramming to regulate non-small cell lung cancer cell growth [27]. The gene discussed is TRIM59; the disease is lung carcinoma.